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Page owners now have a tool to help them delete huge spam runs. Go to /spamdelete and follow the instructions there. It's basically like a 'find and delete' script, so the key to it being effective is to pick out a word or phrase you can search all your comments on that will return *just* the spam comments. In practice this isn't very hard because the spams will often contain a weird URL that is similar over all of them (like 289jwa89423w232.spamhost.com) or it will use the bbcode '[url]' link code that we don't use on this site.
Please let me know if you have any trouble using it.