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SproutCore is Cocoa for the web:
As Apple's public schedule for WWDC explained, "SproutCore is an open source, platform-independent, Cocoa-inspired JavaScript framework for creating web applications that look and feel like Desktop applications.Roughly Drafted has an in depth look at SproutCore in the context of its' closed source competitors: Adobe Flash and Microsoft Silverlight.
Very interesting. I can't wait to check out the MobileMe web apps that Apple is rolling out using this sort of technology.